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vivoChip: The only in vivo imaging and screening device for C. elegans capable of high-resolution, high-content data at high-throughput.

C. elegans and other small model organisms have many advantages over in vitro cell based assays for the phenotypic screening of chemical libraries for drug discovery and toxicology, genetic screens, and for human disease modeling. However their potential has been slowed by an inability to gather the high-resolution imaging data needed to detect subtle phenotypes at the speeds necessary to screen large libraries.

Newormics offers a solution to this problem: the vivoChip. A simple, but elegantly designed microfluidics device with precisely defined channel geometry, that allows lateral alignment and anaesthetic-free immobilization of up to 40 C. elegans or other nematodes, for high resolution imaging in any microscope. vivoChips are available at different scales depending on user need, from microscope slides with 2x individual devices, to multi-well plate format devices with 24x devices for larger screens.

vivoChip applications

  Developmental and reproductive toxicity

  Germline studies

  High-resolution neuronal imaging

  Mutant screening

  Time lapse imaging of developmental events

  RNAi and chemical compound screening

Newormics products

Newormics products

vivoChip technology designed for any lab

Simple control of vivoChip microfluidics

Newormics vivoChip aligns 40 C. elegans side-by-side in a flat plane to reduce the number of images that need to be acquired and processed.

A larger population of animals can also be used in each well due to the precise spacial separation and alignment of each animal, decreasing the number of plates to process.

The vivoChip maximizes the amount of information per pixel by minimizing the 3-dimensional area needed to scan in order to image all animals.

Linear alignment and lateral orientation of the worm bodies facilitates the identification of phenotypes.

Imaging data required to analyze 40 worms in 3D

Plate reader to image 4 low-density wells each containing 10 worms:

16 images × 30 planes x 4 wells = 1920 images

vivoChip to image worms from a single, high-density well containing 40 worms:

4 images × 12 planes  = 48 images