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High-throughput screening

High-content data

vivoChip does both

vivoChip: The first in vivo imaging and screening device for C. elegans capable of high-resolution, high-content data at high throughput speeds.

C. elegans and other small model organisms have many advantages over in vitro cell based assays for phenotypic screening of chemical libraries for neurotoxicity, developmental toxicity, and for performing human disease modeling. However their potential has been slowed by an inability to gather the high-resolution imaging data needed to detect subtle phenotypes induced by test substances at the speeds necessary to screen large libraries.

Newormics products

vivoChip-2x

Small scale vivoChip technology designed for academic labs

vivoCube

Simple control of vivoChip microfluidics

Newormics vivoChip maximizes the amount of information per pixel by minimizing the 3-dimensional area to image. Each device can align 40 C. elegans side-by-side in a flat plane to reduce the number of images that need to be acquired and processed.

A larger population of animals can also be used in each well due to the precise spacial separation and alignment of each animal, decreasing the number of plates to process.

Imaging data required to analyze 40 worms in 3D

Plate reader to image a single well containing 10 worms:

16 images × 15 planes x 4 wells = 1920 images

vivoChip to image a single well containing 40 worms:

16 images × 15 planes  = 48 images

Advantages of C. elegans

Short life-cycle

Transparent body

Precise CRISPR gene editing

Homologous genome

Easy to grow in solid/liquid media

Ethically compatible in vivo model