Neuron-specific toxicity assessment using C. elegans
C. elegans is recognized as a useful alternative in vivo model. The Newormics’ vivoChip® enables the use of C. elegans for high-content, multi-parametric analysis of neurodegeneration phenotypes from high-resolution fluorescence images of neurons. To demonstrate our unique capabilities, we studied dendritic neurodegeneration of dopaminergic neurons in C. elegans induced by a well-accepted neurotoxicant, MPP+, showing dose-dependent increase in neurotoxicity.
This neuron-specific assay provides the ability to assess developmental neurotoxicity in an intact, live, whole animal model. We are currently offering this assay on a fee-for-service basis.